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The most meaningful exception is the Alzheimer’s trial (563 participants), which used validated clinical endpoints and produced null results

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Across randomized trials and meta-analyses in heterogeneous IVF/ICSI populations, melatonin (typically 2–5 mg nocte for 4–12 weeks or during stimulation) increases the number of mature (MII) oocytes, improves fertilization rates, and often enhances embryo quality