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Apart from genomic screening and candidate gene studies, the identification of chromosomal abnormalities and Mendelian syndromes in individuals with autism has helped refine our understanding of the complex genetics underlying these conditions
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One common theme of the observed ETC dysfunction in both muscle and fibroblast culture was that complex dysfunction primarily occurred when evaluating the function of complex III with complex I or II, suggesting that it is the interaction between complex III and complex I or II rather than at complex I or II specifically