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Thioredoxin Glutathione Reductase from Schistosoma mansoni: An Essential Parasite Enzyme and a Key Drug Target | PLOS Medicine
New England Journal of Medicine , 2023 Pivotal Phase II trial demonstrating substantial weight reduction with triple receptor agonism
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The class warnings differ: Tirzepatide warnings (per FDA labeling): Boxed warning: thyroid C-cell tumors based on rodent studies Pancreatitis Acute gallbladder disease Hypoglycemia with concurrent insulin or sulfonylurea Diabetic retinopathy progression in some patients Cagrilintide warnings would only be finalized at FDA approval, which has not occurred